Article
Tyro3 receptor tyrosine kinase contributes to pathogenic phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis and disturbs immune cell balance in experimental arthritis.
Clinical immunology (Orlando, Fla.) - 1 Oct 2023
Wang Ziye, Zhao Zhen, Li Zhichang, Xu Liling, Li Hongchao, Zhu Huaqun, Cheng Gong, Yao RanRan, Pei Wenwen, Liang Ruyu, Liang Renge, Ye Hua, Jiang Shan, Niu Haitao, Sun Xiaolin, Su Yin
Abstract excerpt
Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by synovitis and joint damage, the underlying causes of which remain unclear. Our prior investigations revealed a notable correlation between the expression of Tyro3 Protein Tyrosine Kinase (Tyro3TK) and the progression of RA. To further elucidate the pathogenic role of Tyro3TK in RA, we analyzed the influence of Tyro3TK on pathogenic...
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