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Article

Lobe-specific calcium binding in calmodulin regulates endothelial nitric oxide synthase activation.

PloS one - 1 Jan 2012

Wu Pei-Rung, Kuo Cheng-Chin, Yet Shaw-Fang, Liou Jun-Yang, Wu Kenneth K, Chen Pei-Feng

Abstract excerpt

BACKGROUND: Human endothelial nitric oxide synthase (eNOS) requires calcium-bound calmodulin (CaM) for electron transfer but the detailed mechanism remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using a series of CaM mutants with E to Q substitution at the four calcium-binding sites, we found that single mutation at any calcium-binding site (B1Q, B2Q, B3Q and B4Q) resulted in ∼2-3 fold increase in the CaM...

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PMID: 22768143
DOI: 10.1371/journal.pone.0039851
PMCID: PMC3387242

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Source receipt: pubmed, retrieved 7 Sept 2026.

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