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Article

The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation.

The Journal of biological chemistry - 8 Dec 1995

Su Z, Blazing M A, Fan D, George S E

Abstract excerpt

The neuronal isoform of nitric oxide synthase (nNOS) requires calmodulin for nitric oxide producing activity. Calmodulin functions as a molecular switch, allowing electron transport from the carboxyl-terminal reductase domain of nitric oxide synthase to its heme-containing amino-terminal domain. Available evidence suggests that calmodulin binds to a site between the two domains of nNOS, but it is not known how...

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Source

Identifiers

PMID: 7493936
DOI: 10.1074/jbc.270.49.29117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation.PMID 7493936Read ↗

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