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Article

The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation.

The Journal of biological chemistry - 8 Dec 1995

Su Z, Blazing M A, Fan D, George S E

Abstract excerpt

The neuronal isoform of nitric oxide synthase (nNOS) requires calmodulin for nitric oxide producing activity. Calmodulin functions as a molecular switch, allowing electron transport from the carboxyl-terminal reductase domain of nitric oxide synthase to its heme-containing amino-terminal domain....

Topics

Animals
Calmodulin
Enzyme Activation
Mutation
Nitric Oxide Synthase
Recombinant Fusion Proteins
Structure-Activity Relationship
Swine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7493936
DOI: 10.1074/jbc.270.49.29117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7493936-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation.PMID 7493936Read ↗

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