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Article

Activation of constitutive nitric oxide synthases by oxidized calmodulin mutants.

Biochemistry - 1 Jul 2003

Montgomery Heather J, Bartlett Ryan, Perdicakis Basil, Jervis Eric, Squier Thomas C, Guillemette J Guy

Abstract excerpt

Several calmodulin (CaM) mutants were engineered in an effort to identify the functional implications of the oxidation of individual methionines in CaM on the activity of the constitutive isoforms of nitric oxide synthase (NOS). Site-directed mutagenesis was used to substitute the majority of methionines with leucines. Substitution of all nine methionine residues in CaM with leucines had minimal effects on the...

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PMID: 12820885
DOI: 10.1021/bi027097h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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