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Article

Relaxation of adaptive evolution during the HIV-1 infection owing to reduction of CD4+ T cell counts.

PloS one - 1 Jan 2012

Leal Élcio, Casseb Jorge, Hendry Michael, Busch Michael P, Diaz Ricardo Sobhie

Abstract excerpt

BACKGROUND: The first stages of HIV-1 infection are essential to establish the diversity of virus population within host. It has been suggested that adaptation to host cells and antibody evasion are the leading forces driving HIV evolution at the initial stages of AIDS infection. In order to gain more insights on adaptive HIV-1 evolution, the genetic diversity was evaluated during the infection time in...

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Identifiers

PMID: 22768122
DOI: 10.1371/journal.pone.0039776
PMCID: PMC3387245

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Source receipt: pubmed, retrieved 7 Sept 2026.

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