Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling HIV quasispecies evolutionary dynamics.

BMC evolutionary biology - 16 Aug 2007

Sguanci Luca, Bagnoli Franco, Liò Pietro

Abstract excerpt

BACKGROUND: During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The switch in coreceptor usage has been correlated with a faster progression of the disease to the AIDS phase. As several pharmaceutical companies are starting large phase III trials for R5 and X4 drugs, models...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to HIV Antigens
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Likelihood Functions

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Superinfection

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 17767733
DOI: 10.1186/1471-2148-7-S2-S5
PMCID: PMC1963478

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling HIV quasispecies evolutionary dynamics.PMID 17767733Read ↗

Understanding the HIV coreceptor switch from a dynamical perspective.Semantic proximity Read ↗

HIV-1 tropism dynamics and phylogenetic analysis from longitudinal ultra-deep sequencing data of CCR5- and CXCR4-using variants.Semantic proximity Read ↗

High CD4(+) T-cell surface CXCR4 density as a risk factor for R5 to X4 switch in the course of HIV-1 infection.Semantic proximity Read ↗

Modeling the within-host dynamics of HIV infectionSemantic proximity Read ↗

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort studySemantic proximity Read ↗

Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.Semantic proximity Read ↗

Differences in molecular evolution between switch (R5 to R5X4/X4-tropic) and non-switch (R5-tropic only) HIV-1 populations during infectionSemantic proximity Read ↗

Serial evolutionary networks of within-patient HIV-1 sequences reveal patterns of evolution of X4 strains.Semantic proximity Read ↗

Detection of quasispecies variants predicted to use CXCR4 by ultra-deep pyrosequencing during early HIV infection.Semantic proximity Read ↗

Pathogenesis of HIV infectionSemantic proximity Read ↗

Pairwise comparison of isogenic HIV-1 viruses: R5 phenotype replicates more efficiently than X4 phenotype in primary CD4+ T cells expressing physiological levels of CXCR4.Semantic proximity Read ↗

In vivo evolution of X4 human immunodeficiency virus type 1 variants in the natural course of infection coincides with decreasing sensitivity to CXCR4 antagonists.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.