Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection.

doi:10.1126/science.272.5261.537

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Article

Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection.

Science (New York, N.Y.) - 26 Apr 1996

Wolinsky S M, Korber B T, Neumann A U, Daniels M, Kunstman K J, Whetsell A J, Furtado M R, Cao Y, Ho D D, Safrit J T

Abstract excerpt

The rate of progression to disease varies considerably among individuals infected with human immunodeficiency virus-type 1 (HIV-1). Analyses of semiannual blood samples obtained from six infected men showed that a rapid rate of CD4 T cell loss was associated with relative evolutionary stasis of t...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Animals
Antigenic Variation
Base Sequence
Biological Evolution
CD4 Lymphocyte Count
Cohort Studies
Disease Progression
HIV Antibodies
HIV Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Infections

HIV-1

Histocompatibility Antigens Class I

Humans

Male

Mice

Mice, SCID

Source

Open in PubMed

Identifiers

PMID: 8614801
DOI: 10.1126/science.272.5261.537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8614801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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