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Article

MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas.

Molecular medicine reports - 1 Oct 2012

Sasaki Hidefumi, Shitara Masayuki, Yokota Keisuke, Hikosaka Yu, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka

Abstract excerpt

The expression of multidrug-resistant protein-3 (MRP3), a membrane-bound transporter, has been linked to drug resistance in non-small cell lung cancers (NSCLCs). Recently, we reported that NRF2 gene (NFE2L2) mutations are correlated with poor prognosis for lung squamous cell carcinomas. We hypothesized that tumor MRP3 expression may be correlated with the mutation status of upstream regulators, including NRF2, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22767273
DOI: 10.3892/mmr.2012.979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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