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Article

Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression.

Cancer letters - 1 Nov 2014

Zhu Hongwu, Chen Xiong, Chen Bin, Chen Bei, Fan Jianyong, Song Weibing, Xie Ziying, Jiang Dan, Li Qiuqiong, Zhou Meihua, Sun Dayong, Zhao Yagang

Abstract excerpt

Multidrug resistance (MDR) is a major challenge to the clinical treatment of esophageal cancer. The stress response gene activating transcription factor 4 (ATF4) is involved in homeostasis and cellular protection. However, relatively little is known about the expression and function of ATF4 in esophageal squamous cell carcinoma (ESCC) MDR. In this study, we investigate the potential role and mechanisms of ATF4 in...

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Source

Identifiers

PMID: 25130172
DOI: 10.1016/j.canlet.2014.07.044

Genes

ATF4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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