Article
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.
Breast cancer research : BCR - 1 Jan 2008
Pietersen Alexandra M, Horlings Hugo M, Hauptmann Michael, Langerød Anita, Ajouaou Abderrahim, Cornelissen-Steijger Paulien, Wessels Lodewijk F, Jonkers Jos, van de Vijver Marc J, van Lohuizen Maarten
Abstract excerpt
INTRODUCTION: PolycombGroup (PcG) proteins maintain gene repression through histone modifications and have been implicated in stem cell regulation and cancer. EZH2 is part of Polycomb Repressive Complex 2 (PRC2) and trimethylates H3K27. This histone mark recruits the BMI1-containing PRC1 that silences the genes marked by PRC2. Based on their role in stem cells, EZH2 and BMI1 have been predicted to contribute to a...
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