Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.

Breast cancer research : BCR - 1 Jan 2008

Pietersen Alexandra M, Horlings Hugo M, Hauptmann Michael, Langerød Anita, Ajouaou Abderrahim, Cornelissen-Steijger Paulien, Wessels Lodewijk F, Jonkers Jos, van de Vijver Marc J, van Lohuizen Maarten

Abstract excerpt

INTRODUCTION: PolycombGroup (PcG) proteins maintain gene repression through histone modifications and have been implicated in stem cell regulation and cancer. EZH2 is part of Polycomb Repressive Complex 2 (PRC2) and trimethylates H3K27. This histone mark recruits the BMI1-containing PRC1 that sil...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factor 1
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer of Zeste Homolog 2 Protein

Share to Immunoenzyme Techniques

Share to Polycomb Repressive Complex 1

Share to Polycomb Repressive Complex 2

Share to Proto-Oncogene Proteins

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 19099573
DOI: 10.1186/bcr2214
PMCID: PMC2656906

Genes

BMI1
PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19099573-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.PMID 19099573Read ↗

Aberrant expression of EZH2 is associated with pathological findings and P53 alteration.Semantic proximity Read ↗

Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2.Semantic proximity Read ↗

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes.Semantic proximity Read ↗

Aberrations of EZH2 in cancer.Semantic proximity Read ↗

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.Semantic proximity Read ↗

Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review.Semantic proximity Read ↗

EZH2-associated tumor malignancy: A prominent target for cancer treatment.Semantic proximity Read ↗

EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cellsSemantic proximity Read ↗

Targeting EZH2 in cancer.Semantic proximity Read ↗

Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background.Semantic proximity Read ↗

Role of EZH2 in cancer stem cells: from biological insight to a therapeutic targetSemantic proximity Read ↗

NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.