Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.

Nature - 26 Jul 2012

Straussman Ravid, Morikawa Teppei, Shee Kevin, Barzily-Rokni Michal, Qian Zhi Rong, Du Jinyan, Davis Ashli, Mongare Margaret M, Gould Joshua, Frederick Dennie T, Cooper Zachary A, Chapman Paul B, Solit David B, Ribas Antoni, Lo Roger S, Flaherty Keith T, Ogino Shuji, Wargo Jennifer A, Golub Todd R

Abstract excerpt

Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we developed a co-culture system to systemati...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Sulfonamides
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Growth Factor

Share to Indoles

Share to Proto-Oncogene Proteins c-met

Share to Stromal Cells

Share to Tumor Microenvironment

Share to Vemurafenib

Source

Open in PubMed Open full text

Identifiers

PMID: 22763439
DOI: 10.1038/nature11183
PMCID: PMC3711467

Genes

HGF
BRAF
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22763439-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.PMID 22763439Read ↗

Oncogene Mimicry as a Mechanism of Primary Resistance to BRAF InhibitorsSemantic proximity Read ↗

Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial primingSemantic proximity Read ↗

Dissecting targeted therapy resistance: Integrating models to quantify environment mediated drug resistanceSemantic proximity Read ↗

Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma.Semantic proximity Read ↗

Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axisSemantic proximity Read ↗

HGF/c-MET Axis in Tumor Microenvironment and Metastasis FormationSemantic proximity Read ↗

Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma.Semantic proximity Read ↗

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.Semantic proximity Read ↗

[MET receptor inhibition: Hope against resistance to targeted therapies?]Semantic proximity Read ↗

Fibroblasts Contribute to Melanoma Tumor Growth and Drug ResistanceSemantic proximity Read ↗

Acquisition of mesenchymal-like phenotypes and overproduction of angiogenic factors in lenvatinib-resistant hepatocellular carcinoma cells.Semantic proximity Read ↗

PTHrP drives aggressive traits in colorectal cancer cells: Implications of tumor-stromal cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.