Article

PTHrP drives aggressive traits in colorectal cancer cells: Implications of tumor-stromal cells

2026-04-21

Abstract excerpt

In the tumor microenvironment (TME), dynamic interactions between cells and soluble factors promote tumor progression. We previously demonstrated that parathyroid hormone-related peptide (PTHrP), a TME-associated cytokine, enhances the aggressive phenotype of HCT116 colorectal cancer (CRC) cells, and that conditioned medium from PTHrP-treated HMEC-1 endothelial stromal cells (CM) induces epithelial-to-mesenchymal...

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Literature Corpus work: 57118c21-81b6-52f6-a4c0-9d2522f85040
DOI: 10.64898/2026.04.16.718950

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