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Article

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2009

Wang Wei, Li Qi, Yamada Tadaaki, Matsumoto Kunio, Matsumoto Isao, Oda Makoto, Watanabe Go, Kayano Yoshiyuki, Nishioka Yasuhiko, Sone Saburo, Yano Seiji

Abstract excerpt

PURPOSE: Lung cancers with epidermal growth factor receptor (EGFR)-activating mutations show good clinical response to gefitinib and erlotinib, selective tyrosine kinase inhibitors (TKI) to EGFR, but these tumors invariably develop drug resistance. Host stromal cells have been found to have a considerable effect on the behavior of cancer cells. Little is known, however, about the role of host cells on the...

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Identifiers

PMID: 19843665
DOI: 10.1158/1078-0432.CCR-09-1001

Genes

EGFR
HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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