Article
Acquisition of mesenchymal-like phenotypes and overproduction of angiogenic factors in lenvatinib-resistant hepatocellular carcinoma cells.
Biochemical and biophysical research communications - 16 Apr 2021
Ao Junjie, Chiba Tetsuhiro, Shibata Shuhei, Kurosugi Akane, Qiang Na, Ma Yaojia, Kan Motoyasu, Iwanaga Terunao, Sakuma Takafumi, Kanzaki Hiroaki, Kanayama Kengo, Kojima Ryuta, Kusakabe Yuko, Nakamura Masato, Saito Tomoko, Nakagawa Ryo, Kondo Takayuki, Ogasawara Sadahisa, Suzuki Eiichiro, Muroyama Ryosuke, Kato Jun, Mimura Naoya, Kanda Tatsuo, Maruyama Hitoshi, Kato Naoya
Abstract excerpt
Lenvatinib is one of the first-line drugs for patients with advanced hepatocellular carcinoma (HCC) and widely used around the world. However, the mechanisms underlying resistance to lenvatinib remain unclear. In this study, we conducted characteristic analyses of lenvatinib-resistant HCC cells. Lenvatinib-resistant HCC cell lines were established by exposure to serially escalated doses of lenvatinib over 2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.