Article
Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence.
Genome biology - 1 Jan 2006
Donaldson Ian J, Göttgens Berthold
Abstract excerpt
BACKGROUND: Despite the recent completion of the chimpanzee genome project, few functionally significant sequence differences between humans and chimpanzees have thus far been identified. Alteration in transcriptional regulatory mechanisms represents an important platform for evolutionary change, suggesting that a significant proportion of functional human-chimpanzee sequence differences may affect regulatory...
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