Article
Identification of candidate SNPs for drug induced toxicity from differentially expressed genes in associated tissues.
Gene - 10 Sept 2012
Hasmats Johanna, Kupershmidt Ilya, Rodríguez-Antona Cristina, Su Qiaojuan Jane, Khan Muhammad Suleman, Jara Carlos, Mielgo Xabier, Lundeberg Joakim, Green Henrik
Abstract excerpt
The growing collection of publicly available high-throughput data provides an invaluable resource for generating preliminary in silico data in support of novel hypotheses. In this study we used a cross-dataset meta-analysis strategy to identify novel candidate genes and genetic variations relevant to paclitaxel/carboplatin-induced myelosuppression and neuropathy. We identified genes affected by drug exposure and...
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