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Article

Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2016

Gréen Henrik, Hasmats Johanna, Kupershmidt Ilya, Edsgärd Daniel, de Petris Luigi, Lewensohn Rolf, Blackhall Fiona, Vikingsson Svante, Besse Benjamin, Lindgren Andrea, Brandén Eva, Koyi Hirsh, Peterson Curt, Lundeberg Joakim

Abstract excerpt

PURPOSE: Chemotherapies are associated with significant interindividual variability in therapeutic effect and adverse drug reactions. In lung cancer, the use of gemcitabine and carboplatin induces grade 3 or 4 myelosuppression in about a quarter of the patients, while an equal fraction of patients is basically unaffected in terms of myelosuppressive side effects. We therefore set out to identify genetic markers...

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PMID: 26378035
DOI: 10.1158/1078-0432.CCR-15-0964

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DDX53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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