Chromosome instability in cancer: how, when, and why?

Abstract excerpt

The majority of malignant tumors exhibit complex genomic aberrations, and it has been suggested that an elevated rate of chromosome mutation is present in neoplastic cells. This chromosomal evolution is probably initiated at a preinvase stage and then proceeds continuously but at variable rates during tumor progression. Even though the initiating events may vary among neoplasms, the end point is often a similar...

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