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Persistent <scp>DNA</scp> damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells

26 Jan 2015

Abstract excerpt

Human mesenchymal stem cells (hMSCs) are adult multipotent stem cells located in various tissues, including the bone marrow. In contrast to terminally differentiated somatic cells, adult stem cells must persist and function throughout life to ensure tissue homeostasis and repair. For this reason, they must be equipped with DNA damage responses able to maintain genomic integrity while ensuring their lifelong...

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PMID: 25619736
DOI: 10.1111/jcmm.12387

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