Article
Multiple mechanisms account for genomic instability and molecular mutation in neoplastic transformation.
Clinical chemistry - 1 May 1995
Coleman W B, Tsongalis G J
Abstract excerpt
Neoplastic cells typically possess numerous genomic mutations and chromosomal aberrations, including point mutations, gene amplifications and deletions, and replication errors. Acquisition of such genomic instability may represent an early step in the process of carcinogenesis. Proteins involved...
Topics
- Animals
- Cell Cycle
- Cell Transformation, Neoplastic
- DNA Damage
- DNA Repair
- Genome
- Genome, Human
- Humans
- Mutation
- Proto-Oncogenes