Article
Functional characterization of the novel BRAF complex mutation, BRAF(V600delinsYM) , identified in papillary thyroid carcinoma.
International journal of cancer - 1 Feb 2013
Matsuse Michiko, Mitsutake Norisato, Tanimura Susumu, Ogi Tomoo, Nishihara Eijun, Hirokawa Mitsuyoshi, Fuziwara Cesar S, Saenko Vladimir A, Suzuki Keiji, Miyauchi Akira, Yamashita Shunichi
Abstract excerpt
An activating mutation in the BRAF gene is the most common genetic alteration in papillary thyroid carcinomas (PTCs). The mutation in PTCs is almost a c.1799T>A transversion, resulting in a p.V600E amino acid substitution (BRAF(V600E) ). Here, we report a novel complex BRAF mutation identified in 4/492 Japanese PTC cases (0.81%). The mutation was comprised of one nucleotide substitution at position 1798, followed...
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