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Article

Characterization of a novel complex BRAF mutation in a follicular variant papillary thyroid carcinoma.

European journal of endocrinology - 1 Jul 2008

Barzon Luisa, Masi Giulia, Boschin Isabella Merante, Lavezzo Enrico, Pacenti Monia, Casal Ide Eric, Toniato Antonio, Toppo Stefano, Palù Giorgio, Pelizzo Maria Rosa

Abstract excerpt

INTRODUCTION: Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent BRAF mutations seem to be associated with other PTC histotypes. CASE: Screening for activating...

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Topics

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Share to Amino Acid Sequence
Share to Carcinoma, Papillary, Follicular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRAF gene

Share to Mutation

Share to Protein Structure, Secondary

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 18426810
DOI: 10.1530/EJE-08-0239

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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