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Article

Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers.

The Journal of clinical endocrinology and metabolism - 1 Sept 2003

Namba Hiroyuki, Nakashima Masahiro, Hayashi Tomayoshi, Hayashida Naomi, Maeda Shigeto, Rogounovitch Tatiana I, Ohtsuru Akira, Saenko Vladimir A, Kanematsu Takashi, Yamashita Shunichi

Abstract excerpt

Activating mutations in the BRAF kinase gene have recently been reported in human cancers. The aim of the present study was to determine the frequency of BRAF mutations in thyroid cancer and their correlation with clinicopathological parameters. We analyzed exons 11 and 15 of BRAF gene in six human thyroid cancer cell lines and 207 paraffin-embedded thyroid tumor tissues. A missense mutation was found at T1796A...

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Source

Identifiers

PMID: 12970315
DOI: 10.1210/jc.2003-030305

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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