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Article

Role of BRAF in thyroid oncogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2011

Caronia Lisa M, Phay John E, Shah Manisha H

Abstract excerpt

BRAF, a cytoplasmic serine-threonine protein kinase, plays a critical role in cell signaling as an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common BRAF mutation is the V600E transversion, which causes constitutive kinase activity. This mutation has been found in a multitude of human cancers, including both papillary thyroid cancer (PTC) and papillary-derived anaplastic...

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Source

Identifiers

PMID: 21900390
DOI: 10.1158/1078-0432.CCR-11-1155

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeting of the BRAF gene in papillary thyroid carcinoma (review).Semantic proximity Read ↗

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