Article
Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence in an Inbred Population of Pakistan.
Diabetes - 1 Jul 2020
Saeed Sadia, Arslan Muhammad, Manzoor Jaida, Din Sadia M, Janjua Qasim M, Ayesha Hina, Ain Qura-Tul, Inam Laraib, Lobbens Stephane, Vaillant Emmanuel, Durand Emmanuelle, Derhourhi Mehdi, Amanzougarene Souhila, Badreddine Alaa, Berberian Lionel, Gaget Stefan, Khan Waqas I, Butt Taeed A, Bonnefond Amélie, Froguel Philippe
Abstract excerpt
Monogenic forms of obesity have been identified in ≤10% of severely obese European patients. However, the overall spectrum of deleterious variants (point mutations and structural variants) responsible for childhood severe obesity remains elusive. In this study, we genetically screened 225 severely obese children from consanguineous Pakistani families through a combination of techniques, including an...
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