Article
ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2012
Ishii Akihiro, Fyffe-Maricich Sharyl L, Furusho Miki, Miller Robert H, Bansal Rashmi
Abstract excerpt
Wrapping of the myelin sheath around axons by oligodendrocytes is critical for the rapid conduction of electrical signals required for the normal functioning of the CNS. Myelination is a multistep process where oligodendrocytes progress through a well coordinated differentiation program regulated by multiple extracellular growth and differentiation signals. The intracellular transduction of the extracellular...
Topics
- 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
- Age Factors
- Animals
- Antigens
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Female
- MAP Kinase Signaling System
- Male