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Article

FGF9 modulates Schwann cell myelination in developing nerves and induces a pro-inflammatory environment during injury.

Journal of cellular biochemistry - 1 Nov 2018

Deng Binbin, Lv Wenjing, Duan Weisong, Liu Yakun, Li Zhongyao, Song Xueqing, Cui Can, Qi Xiaoming, Wang Xiaoxiao, Li Chunyan

Abstract excerpt

Myelin sheath is critical for the proper functioning of the peripheral nervous system (PNS), which allows the effective conduction of nerve impulses. Fibroblast growth factor 9 (FGF9) is an autocrine and paracrine protein in the fibroblast growth factor family that regulates cell differentiation and proliferation. Fgf9 Schwann cell (SC) conditional knockout mice were developed to detect the role of FGF9 in the...

Topics

Animals
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Apoptosis
Axons
B7-2 Antigen
Behavior, Animal
Fibroblast Growth Factor 9
Gene Knockout Techniques
Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-1beta

MAP Kinase Signaling System

Mice

Mice, Inbred C57BL

Mice, Knockout

Mutation

Myelin Sheath

Neurogenesis

Source

Identifiers

PMID: 29953642
DOI: 10.1002/jcb.27105

Genes

FGF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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