Article
Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 May 2012
Furusho Miki, Dupree Jeffrey L, Nave Klaus-Armin, Bansal Rashmi
Abstract excerpt
Formation of the CNS white matter is developmentally tightly regulated, but the molecules and mechanisms of myelination control in the postnatal CNS are poorly understood. Here, we show that myelin growth is controlled by fibroblast growth factor (FGF) signaling, originally identified as a proliferative signal for oligodendrocyte precursor cells (OPCs) in vitro. We created two lines of mice lacking both FGF...
Topics
- Animals
- Animals, Newborn
- Cells, Cultured
- Female
- Male
- Mice
- Mice, Knockout
- Mutation
- Myelin Sheath
- Oligodendroglia
- Receptor, Fibroblast Growth Factor, Type 1