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Article

Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.

Development (Cambridge, England) - 1 Aug 2012

Stinchfield Michael J, Takaesu Norma T, Quijano Janine C, Castillo Ashley M, Tiusanen Nina, Shimmi Osamu, Enzo Elena, Dupont Sirio, Piccolo Stefano, Newfeld Stuart J

Abstract excerpt

The ability of secreted Transforming Growth Factor β (TGFβ) proteins to act as morphogens dictates that their influence be strictly regulated. Here, we report that maternally contributed fat facets (faf; a homolog of USP9X/FAM) is essential for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that patterns the embryonic dorsal-ventral axis. The data suggest that the loss of faf...

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Identifiers

PMID: 22745309
DOI: 10.1242/dev.077206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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