Article
The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development.
Mechanisms of development - 1 Nov 1997
Isaksson A, Peverali F A, Kockel L, Mlodzik M, Bohmann D
Abstract excerpt
The Drosophila fat facets (faf) gene encodes a deubiquitination enzyme with a putative function in proteasomal protein degradation. Mutants lacking zygotic faf function develop to adulthood, but have rough eyes caused by the presence of one to two ectopic outer photoreceptors per ommatidium. Here...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Drosophila
- Drosophila Proteins
- Endopeptidases
- Eye
- Eye Proteins
- Gene Expression Regulation, Developmental
- Membrane Glycoproteins
- Mutation
- Phenotype
- Photoreceptor Cells, Invertebrate
- Proto-Oncogene Proteins c-jun
- Receptor Protein-Tyrosine Kinases
- Signal Transduction
- Transcription Factors
- Ubiquitins
- ras Proteins