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Article

The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis.

Development (Cambridge, England) - 1 Apr 2000

Cadavid A L, Ginzel A, Fischer J A

Abstract excerpt

Fat facets is a deubiquitinating enzyme required in a cell communication pathway that limits to eight the number of photoreceptor cells in each facet of the Drososphila compound eye. Genetic data support a model whereby Faf removes ubiquitin, a polypeptide tag for protein degradation, from a specific ubiquitinated protein thus preventing its degradation. Here, mutations in the liquid facets gene were identified...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10725248
DOI: 10.1242/dev.127.8.1727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis.PMID 10725248Read ↗

Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.Semantic proximity Read ↗

Identification of genes that interact with Drosophila liquid facets.Semantic proximity Read ↗

Mutagenesis screens for interacting genes reveal three roles for fat facets during Drosophila eye development.Semantic proximity Read ↗

Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.Semantic proximity Read ↗

Genetic analysis of the role of the drosophila fat facets gene in the ubiquitin pathway.Semantic proximity Read ↗

Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning.Semantic proximity Read ↗

In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene.Semantic proximity Read ↗

Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye.Semantic proximity Read ↗

The Drosophila epsin 1 is required for ubiquitin-dependent synaptic growth and function but not for synaptic vesicle recycling.Semantic proximity Read ↗

The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development.Semantic proximity Read ↗

The fat facets gene is required for Drosophila eye and embryo development.Semantic proximity Read ↗

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