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Article

Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.

BMC medical genetics - 19 Sept 2007

Seshadri Sudha, DeStefano Anita L, Au Rhoda, Massaro Joseph M, Beiser Alexa S, Kelly-Hayes Margaret, Kase Carlos S, D'Agostino Ralph B, Decarli Charles, Atwood Larry D, Wolf Philip A

Abstract excerpt

BACKGROUND: Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD). We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample. METHODS: A total of 705 stroke- and dementia-free Framingham...

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Identifiers

PMID: 17903297
DOI: 10.1186/1471-2350-8-S1-S15
PMCID: PMC1995608

Genes

SORL1
CDH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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