Article
No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and Henoch-Schönlein purpura.
Tissue antigens - 1 Dec 2013
López-Mejías R, Sevilla Pérez B, Genre F, Castañeda S, Ortego-Centeno N, Llorca J, Ubilla B, Ochoa R, Pina T, Marquez A, Sala-Icardo L, Miranda-Filloy J A, Rueda-Gotor J, Martín J, Blanco R, González-Gay M A
Abstract excerpt
Henoch-Schönlein purpura (HSP) is the most common type of primary small-sized blood vessel vasculitis in children and an uncommon condition in adults. Interleukin (IL)-6 is a proinflammatory cytokine whose effect is controlled by the IL-6 receptor (IL-6R). IL-6 transducer (IL-6ST/gp130) is the signal-transducing subunit of the IL-6R. Two hundred and eighty five Spanish HSP patients and 877 sex and ethnically...
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