Article
The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis.
Genes and immunity - 1 Feb 2012
Martin J-E, Carmona F D, Broen J C A, Simeón C P, Vonk M C, Carreira P, Ríos-Fernández R, Espinosa G, Vicente-Rabaneda E, Tolosa C, García-Hernández F J, Castellví I, Fonollosa V, González-Gay M A, Sáez-Comet L, Portales R García, de la Peña P García, Fernández-Castro M, Díaz B, Martínez-Estupiñán L, Coenen M, Voskuyl A E, Schuerwegh A J, Vanthuyne M, Houssiau F, Smith V, de Keyser F, De Langhe E, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Palm Ø, Chee M M, van Laar J M, Denton C, Herrick A, Worthington J, Koeleman B P C, Radstake T R D J, Fonseca C, Martín J
Abstract excerpt
Regulatory T cells (T(regs)) are crucial in the maintenance of the immune tolerance and seem to have an important role in systemic sclerosis (SSc). The interleukin 2 receptor α (IL2RA) is an important T(reg) marker, and polymorphisms of IL2RA gene are associated with a number of autoimmune diseases. Therefore, we aimed to investigate for the first time the association of the IL2RA locus in SSc. For this purpose,...
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