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Article

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging.

The Journal of biological chemistry - 19 Jan 2018

Montpas Nicolas, St-Onge Geneviève, Nama Nassr, Rhainds David, Benredjem Besma, Girard Mélanie, Hickson Gilles, Pons Véronique, Heveker Nikolaus

Abstract excerpt

The atypical chemokine receptor ACKR3 contributes to chemotaxis by binding, internalizing, and degrading the chemokines CXCL11 and CXCL12 to shape and terminate chemotactic gradients during development and immune responses. Although unable to trigger G protein activation, both ligands activate G protein-independent ACKR3 responses and prompt arrestin recruitment. This offers a model to specifically study...

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Source

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Identifiers

PMID: 29180449
DOI: 10.1074/jbc.M117.814947
PMCID: PMC5777261

Genes

ACKR3
CXCL11
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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