Article

<i>In vivo</i> expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

2023-07-29

Abstract excerpt

Homology Directed Repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms in terminally differentiated tissues. Here, we tested “Repair Drive”, a novel method for improving targeted gene insertion in the liver by selectively expanding correctly repaired hepatocytes in vivo...

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Literature Corpus work: 4bcb4bb6-6049-589b-912b-687c3b6d6671
DOI: 10.1101/2023.07.26.550728

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