Article
A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver.
BMC biology - 1 Apr 2022
Kopasz Anna Georgina, Pusztai Dávid Zsolt, Karkas Réka, Hudoba Liza, Abdullah Khaldoon Sadiq Ahmed, Imre Gergely, Pankotai-Bodó Gabriella, Migh Ede, Nagy Andrea, Kriston András, Germán Péter, Drubi Andrea Bakné, Molnár Anna, Fekete Ildikó, Dani Virág Éva, Ocsovszki Imre, Puskás László Géza, Horváth Péter, Sükösd Farkas, Mátés Lajos
Abstract excerpt
BACKGROUND: Understanding the contribution of gene function in distinct organ systems to the pathogenesis of human diseases in biomedical research requires modifying gene expression through the generation of gain- and loss-of-function phenotypes in model organisms, for instance, the mouse. However, methods to modify both germline and somatic genomes have important limitations that prevent easy, strong, and stable...
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