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Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.

ACS chemical biology - 18 Sept 2020

Xiao Xiansha, Elsayed Somayah S, Wu Changsheng, van der Heul Helga U, Metsä-Ketelä Mikko, Du Chao, Prota Andrea E, Chen Chun-Chi, Liu Weidong, Guo Rey-Ting, Abrahams Jan Pieter, van Wezel Gilles P

Abstract excerpt

Angucyclines are a structurally diverse class of actinobacterial natural products defined by their varied polycyclic ring systems, which display a wide range of biological activities. We recently discovered lugdunomycin (1), a highly rearranged polyketide antibiotic derived from the angucycline backbone that is synthesized via several yet unexplained enzymatic reactions. Here, we show via in vivo, in vitro, and...

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Identifiers

PMID: 32840360
DOI: 10.1021/acschembio.0c00564
PMCID: PMC7506943

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C6

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