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Article

Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells

24 Jun 2012

Abstract excerpt

PURPOSE: Endothelin-1 (ET-1), synthesized in vascular endothelial cells, is a potent vasoconstrictor. ET-1-related vascular abnormality has been known to be important in the pathogenesis of glaucoma, especially in normal tension glaucoma. However, the long-term effect of increased vascular ET-1 on the retinal tissue is still unclear. METHODS: The mice with overexpression of ET-1 in vascular endothelial cells...

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PMID: 22729434
DOI: 10.1167/iovs.12-9999

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