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Article

Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation

26 Sept 2020

Abstract excerpt

Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs), the output neurons of the retina. Multiple lines of evidence show the endothelin (EDN, also known as ET) system is important in glaucomatous neurodegeneration. To date, the molecular mechanisms within RGCs driving EDN-induced RGC death have not been clarified. The pro-apoptotic transcription factor JUN (the...

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PMID: 32980857
DOI: 10.1038/s41419-020-02990-0

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