Article

Endothelin 2–Mediated Neuroinflammation Drives Hypertension-Associated Retinal Dysfunction

2026-01-28

Abstract excerpt

Systemic hypertension is a significant risk factor for glaucoma, a leading cause of irreversible blindness, yet the mechanistic basis connecting the two conditions remains elusive. Here, we demonstrate that hypertensive rats develop accelerated retinal degeneration characterized by retinal thinning, functional impairment, reduced perfusion, and progressive neuroinflammation. Critically, these changes occur despite...

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Literature Corpus work: aeba19a5-a65a-5a39-a86f-3b3624d8004f
DOI: 10.64898/2026.01.26.701756

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