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Article

Advanced Age Worsens Phenotypes of Ocular Hypertension in Mice.

Aging and disease - 28 May 2025

Pitale Priyamvada M, Gibson Solomon E, Keehn Caroline C, Yazdian Arman T, Shen Guofu, Frankfort Benjamin J

Abstract excerpt

Glaucoma is a neurodegenerative disorder of the optic nerve and retinal ganglion cells (RGCs) and a major cause of blindness. The two most important risk factors for glaucoma are ocular hypertension (OHT) and advanced age. In this study, we explored the combined impact of aging and OHT on retinal neuronal and microvasculature health. We induced OHT using the bead-injection model in 12 week old (young) and 1.5...

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Share to Glaucoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 40479574
DOI: 10.14336/AD.2025.0349
PMCID: PMC13061565

Genes

ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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