Genetic analysis of the IL8 gene polymorphism (rs4073) in generalized aggressive periodontitis.

doi:10.1016/j.archoralbio.2012.05.008

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Article

Genetic analysis of the IL8 gene polymorphism (rs4073) in generalized aggressive periodontitis.

Archives of oral biology - 1 Feb 2013

Andia Denise Carleto, Letra Ariadne, Casarin Renato Corrêa Viana, Casati Marcio Zaffalon, Line Sergio Roberto Peres, de Souza Ana Paula

Abstract excerpt

OBJECTIVES: Interleukin (IL)-8 is an important chemokine for regulation of the inflammatory response. A single nucleotide polymorphism (SNP) reference sequence (rs) 4073 in the IL8 gene has been shown to regulate IL-8 levels after stimulation with lipopolysaccharide. This study investigates the transmission pattern of the IL8 rs4073 risk allele A and its association with susceptibility to aggressive periodontitis...

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Identifiers

PMID: 22727395
DOI: 10.1016/j.archoralbio.2012.05.008
PMCID: PMC3459305

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