Article
Interleukin-8 gene promoter polymorphism (rs4073) may contribute to chronic periodontitis.
Journal of periodontology - 1 Jun 2011
Andia Denise C, de Oliveira Naila F P, Letra Ariadne M, Nociti Francisco H, Line Sergio R P, de Souza Ana P
Abstract excerpt
BACKGROUND: The proinflammatory chemokine interleukin (IL)-8 is important in the regulation of the inflammatory response. Analyses of the single nucleotide polymorphism (SNP) reference sequence (rs) 4073 showed that the A allele upregulated IL-8 levels after stimulation with lipopolysaccharides. We investigated the association of the SNP rs4073 with chronic periodontitis. METHODS: Genotyping was performed by a...
Topics
- Adult
- Alleles
- Brazil
- Case-Control Studies
- Chronic Periodontitis
- Female
- Gene Frequency
- Haplotypes
- Humans