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Article

Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.

Breast cancer research and treatment - 1 Dec 2011

Vuorela Mikko, Pylkäs Katri, Hartikainen Jaana M, Sundfeldt Karin, Lindblom Annika, von Wachenfeldt Wäppling Anna, Haanpää Maria, Puistola Ulla, Rosengren Annika, Anttila Maarit, Kosma Veli-Matti, Mannermaa Arto, Winqvist Robert

Abstract excerpt

RAD51C, a RAD51 paralogue involved in homologous recombination, is a recently established Fanconi anemia and breast cancer predisposing factor. In the initial report, RAD51C mutations were shown to confer a high risk for both breast and ovarian tumors, but most of the replication studies published so far have failed to identify any additional susceptibility alleles. Here, we report a full mutation screening of...

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Identifiers

PMID: 21750962
DOI: 10.1007/s10549-011-1677-x

Genes

RAD51

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Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.PMID 21750962Read ↗

RAD51C is a susceptibility gene for ovarian cancer.Semantic proximity Read ↗

Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.Semantic proximity Read ↗

Germline RAD51C mutations in ovarian cancer susceptibility.Semantic proximity Read ↗

RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.Semantic proximity Read ↗

Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families.Semantic proximity Read ↗

Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.Semantic proximity Read ↗

RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.Semantic proximity Read ↗

RAD51B in Familial Breast Cancer.Semantic proximity Read ↗

Germline mutations in RAD51C and RAD51D and hereditary predisposition to ovarian cancer.Semantic proximity Read ↗

Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.Semantic proximity Read ↗

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patientsSemantic proximity Read ↗

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