Article
A genetically defined animal model of anembryonic pregnancy.
Human reproduction (Oxford, England) - 1 Aug 1993
West J D
Abstract excerpt
Mutant mouse conceptuses, homozygous for a defect in the gene encoding the glycolytic enzyme, glucose phosphate isomerase (GPI) died in utero by 9 1/2 days post coitum. By this stage there was no normal embryo, but trophoblast and some extra-embryonic membranes usually survived. The morphology of...
Topics
- Animals
- Decidua
- Disease Models, Animal
- Embryo Implantation
- Energy Metabolism
- Female
- Glucose-6-Phosphate Isomerase
- Glycolysis
- Hydatidiform Mole
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Pregnancy
- Trophoblasts
- Uterine Neoplasms