Article
Maternal enzyme masks the phenotype of mouse embryos lacking dihydrolipoamide dehydrogenase.
Reproductive biomedicine online - 1 Jul 2009
Johnson Mark, Vang Pa, Filipovits Jessica, Gardner David
Abstract excerpt
During early embryogenesis, the phenotype reflecting the embryonic genotype emerges only as maternal proteins are replaced by embryonically encoded forms, a process known as the maternal-to-embryonic transition (MET). Little is understood about MET for most proteins. This study investigates how complete deficiency of the murine dihydrolipoamide dehydrogenase gene (Dld), a gene that encodes an enzyme of...
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