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Article

Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis.

EMBO reports - 1 Nov 2010

Zheng Wenjing, Gorre Nagaraju, Shen Yan, Noda Tetsuo, Ogawa Wataru, Lundin Eva, Liu Kui

Abstract excerpt

Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression...

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Identifiers

PMID: 20930845
DOI: 10.1038/embor.2010.144
PMCID: PMC2966953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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