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Article

Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach.

PloS one - 1 Jan 2012

Lyngdoh Tanica, Vuistiner Philippe, Marques-Vidal Pedro, Rousson Valentin, Waeber Gérard, Vollenweider Peter, Bochud Murielle

Abstract excerpt

BACKGROUND: Although the relationship between serum uric acid (SUA) and adiposity is well established, the direction of the causality is still unclear in the presence of conflicting evidences. We used a bidirectional Mendelian randomization approach to explore the nature and direction of causality between SUA and adiposity in a population-based study of Caucasians aged 35 to 75 years. METHODS AND FINDINGS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22723994
DOI: 10.1371/journal.pone.0039321
PMCID: PMC3378571

Genes

FTO
TMEM18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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