Article
Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
The Journal of clinical endocrinology and metabolism - 14 Jul 2022
Li Shiwei, Fu Yuhong, Liu Yue, Zhang Xinxin, Li Haijun, Tian Lei, Zhuo Lin, Liu Ming, Cui Jingqiu
Abstract excerpt
BACKGROUND: Observational studies have shown that nonalcoholic fatty liver disease (NAFLD) is highly correlated with serum uric acid (SUA). However, these studies have an inherent risk of bias due to reverse causality. Here, we perform a Mendelian randomization (MR) study to investigate causality between SUA and NAFLD. METHODS: We performed a 2-sample bidirectional MR analysis using summary-level data from...
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